Progress in molecular biology of myelodysplastic syndromes with trisomy 8 / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
; (12): 497-501, 2018.
Article
de Zh
| WPRIM
| ID: wpr-807303
Bibliothèque responsable:
WPRO
ABSTRACT
Myelodysplastic syndrome (MDS) is a heterogeneous group of myeloid clonal disease deriving from hematopoietic stem cells, which is mainly characterized with bone marrow failure and abnormal cloning. Trisomy 8 is the most common chromosomal abnormality in MDS. Current studies have found that gene amplification, gene mutation, abnormal expression of microRNA, high expression of Wilms tumor 1 protein, Survivin and miR-661 are related to trisomy 8, which play roles in the abnormality of clone and apoptosis of MDS. This article summarizes the molecular biology transformation and clinical treatment progress of MDS with trisomy 8.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Journal of Leukemia & Lymphoma
Année:
2018
Type:
Article