Prevention of hydromorphone on postoperative hyperpathia in patients receiving remifentanil combined anesthesia / 中国基层医药

ABSTRACT

Objective@#To explore the clinical effect of hydromorphone in the prevention of postoperative hyperpathia in patients receiving remifentanil combined anesthesia.@*Methods@#64 patients who were scheduled to receive abdominal surgery and postoperative analgesia were randomly divided into hydromorphone group(n=32) and control group (n=32) according to random number table.All the cases were given PCIA after surgery, the control group was given fentanyl 12.5μg/kg, and the hydromorphone group was given fentanyl 12.5μg/kg + hydromorphone 10μg/kg.The postoperative analgesic effects at different time, postoperative recovery, usage of PCIA and incidence of adverse effects in two groups were compared.@*Results@#There were no statistically significant differences in respiration recovery time, wake-up time, extubation time between the two groups (t=1.21, 0.83, 0.33, all P>0.05). The levels of MAP, HR after extubation of the hydromorphone group were significantly lower than those of the control group (t=2.84, 2.66, all P<0.05). The VAS scores at 30 min, 1h, 2h, 4h, 12h after operation in the hydromorphone group were significantly lower than those in the control group (t=8.83, 5.25, 8.77, 9.51, 9.69, all P<0.05), while the difference was not statistically significant between the two groups at 24h after operation (t=1.87, P>0.05). The press times and dosage of fentanyl during 1h, 24h after surgery of the hydromorphone group were significantly less than those of the control group(t=16.71, 36.38, 43.05, 10.98, all P<0.05). The adverse reactions between the two groups had no statistically statistical difference (χ2=0.14, P>0.05).@*Conclusion@#Postoperative analgesia of remifentanil combined anesthesia with hydromorphone can effectively prevent RIH, reduce other anesthetics dose, and does not increase the risk of complications.