Research progress in innate immune mechanisms during influenza A virus infection / 中华实验和临床病毒学杂志

ABSTRACT

Influenza A virus is an enveloped virus of the Orthomyxoviridae family. Acute fever, generalized pain, fatigue and respiratory symptoms are the typical symptoms after influenza A virus infection. Influenza A virus triggers the activation of signaling pathways that are dependent on host pattern recognition receptors (PRRs) including toll-like receptors (TLRs), retinoic acid-inducible gene I receptors (RLRs) and NLRs. Then these signaling pathways activate downstream transcript factors that induce expression of various interferons and cytokines (IL-1, IL-18). This review will elaborate the mechanisms of these PRRs.