Paget's Disease of Bone Affecting Peripheral Limb: Difficulties in Diagnosis: A Case Report
Journal of Bone Metabolism
;
: 71-75, 2020.
Article
Dans Anglais
| WPRIM
| ID: wpr-811182
ABSTRACT
In terms of management of Paget's disease of bone (PDB), early diagnosis and proper management achieving remission is essential with lifelong specialist follow-up. We present the case of a 40-year-old woman with PDB affecting mainly the distal extremities (ankle and wrist). The patient visited our hospital in 2012 with heel pain. Plain radiography revealed osteoporosis, and a bone scan revealed hot uptake. Initial laboratory investigations showed normal serum calcium, 25-hydroxy-vitamin D, and parathyroid hormone levels; however, osteocalcin, C-terminal telopeptide of type I collagen, and bone alkaline phosphatase levels were elevated. A bone mineral density scan showed T- and Z-scores of −2.5 and −2.7, respectively, and bisphosphonate treatment was initiated. Biopsy performed on the calcaneal lateral wall revealed inconclusive findings. Follow-up biopsy on the left distal radius was performed 7 years later to investigate wrist pain, and this examination led to a final diagnosis as PDB. We suggest inconclusive biopsy result during the early phase of PDB and highly recommend follow-up evaluation in osteoporosis with atypical behavior.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Maladie de Paget des os
/
Ostéoporose
/
Hormone parathyroïdienne
/
Radius
/
Spécialisation
/
Poignet
/
Biopsie
/
Talon
/
Radiographie
/
Densité osseuse
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Étude pronostique
/
Étude de dépistage
Limites du sujet:
Adulte
/
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Journal of Bone Metabolism
Année:
2020
Type:
Article
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