A reliable crystallization process for the preparation of agomelatine form I / 中国药科大学学报
Journal of China Pharmaceutical University
;
(6): 171-175, 2016.
Article
Dans Chinois
| WPRIM
| ID: wpr-811801
ABSTRACT
@#A reliable crystallization process was developed for the preparation of stable agomelatine form I. This antisolvent crystallization was explored in ethanol-n-heptane by adding PVP and ethanol-water system by adding HPMC, respectively. Factors such as solvent, polymer, concentration of polymer, and solvent ratio were subjected to detailed examination. Accelerated and long-term stability observations indicates that the presence of polymeric additives in the crystallization process enhances the stability of agomelatine form I.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Journal of China Pharmaceutical University
Année:
2016
Type:
Article
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