Inhibitory effect of diarylheptanoids from Alpinia oxyphylla on angiogenesis / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 85-88, 2015.
Article
de Zh
| WPRIM
| ID: wpr-811916
Bibliothèque responsable:
WPRO
ABSTRACT
@#This study investigated the anti-angiogenic activities of two diarylheptanoids, together with a structure analogue, curcumin. The activity and toxicity of these three compounds were compared using transgenic zebrafish as in vivo model and human umbilical vein endothelial cell(HUVEC)as in vitro model. Anti-angiogenic index(AI)was used as the ratio between LC50 and EC50. The results suggested that in both in vitro and in vivo assay, curcumin exerted the most potent anti-angiogenic effect but with lowest toxicity among these compounds; Yakuchinone A was the second potent; Yakuchinone B has the lowest activity but with the highest toxicity in all three compounds. Taken together, curcumin was the best angiogenic inhibitor in these three diarylheptanoids.
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Indice:
WPRIM
langue:
Zh
Texte intégral:
Journal of China Pharmaceutical University
Année:
2015
Type:
Article