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Synthesis of(Z)-methyl-2-acetamidocinnamate / 中国药科大学学报
Journal of China Pharmaceutical University ; (6): 178-180, 2015.
Article Dans Chinois | WPRIM | ID: wpr-811930
ABSTRACT
@#In the investigation of asymmetric catalytic hydrogenation reaction, (Z)-methyl-2-acetamidocinnamate is often used as a standard substrate to assess the chiral catalysts. However, its previous syntheses suffered from low yield, relying on column chromatography for isolation. Herein, (Z)-methyl-2-acetamidocinnamate was obtained with 68. 5% isolation yield via simple operations such as wash and extraction using dicyclohexylcarbodiimide(DCC)as dehydrant and 4-dimethylaminopyridine(DMAP)as catalyst in the last synthetic step.

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) langue: Chinois Texte intégral: Journal of China Pharmaceutical University Année: 2015 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) langue: Chinois Texte intégral: Journal of China Pharmaceutical University Année: 2015 Type: Article