Synthesis and cytotoxicity of longistylin C derivatives / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 311-315, 2015.
Article
de En
| WPRIM
| ID: wpr-812140
Bibliothèque responsable:
WPRO
ABSTRACT
The present study was designed to identify potent anti-tumor compounds from a series of new longistylin C derivatives. Ten longistylin C derivatives were synthesized and their structures were confirmed by (1)H NMR, MS, and elemental analyses. Their cytotoxicity in vitro against three human cancer cell lines (A549, HepG2, and MCF-7) were evaluated by the MTT assay. Among these compounds, DT-6 and DT-9 displayed much better cytotoxicity against A549, HepG2, and MCF-7 cells, DT-1 exhibited selective cytotoxicity against HepG2, and the structure-activity relationships were investigated. In conclusion, Compounds DT-6 and DT-9 may serve as potential lead compounds for the discovery of new anti-cancer drugs.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacologie
/
Relation structure-activité
/
Tests de criblage d'agents antitumoraux
/
Lignée cellulaire tumorale
/
Antinéoplasiques
Limites du sujet:
Humans
langue:
En
Texte intégral:
Chinese Journal of Natural Medicines (English Ed.)
Année:
2015
Type:
Article