Absolute configuration of podophyllotoxone and its inhibitory activity against human prostate cancer cells / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 59-64, 2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-812173
ABSTRACT
Podophyllotoxone (1) was isolated from the roots of Dysosma versipellis. The structure was determined by spectroscopic analysis in combination with single-crystal X-ray analysis. The absolute configuration of compound 1 was assigned based on the Flack parameter. It showed significant inhibitory activities against human prostate cancer cells PC3 and DU145 with IC50 values being 14.7 and 20.6 μmol·L(-1), respectively. It also arrested the cells at G2/M phase. Tubulin polymerization assay showed that it inhibited the tubulin polymerization in a dose-dependent manner, and molecular docking analysis revealed a different binding mode with tubulin as compared with those known tubulin inhibitors.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Podophyllotoxine
/
Tumeurs de la prostate
/
Tubuline
/
Extraits de plantes
/
Chimie
/
Phase G2
/
Racines de plante
/
Berberidaceae
/
Lignée cellulaire tumorale
Limites du sujet:
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Chinese Journal of Natural Medicines (English Ed.)
Année:
2015
Type:
Article
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