Scopariusols L-T, nine new ent-kaurane diterpenoids isolated from Isodon scoparius / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 456-464, 2018.
Article
Dans Anglais
| WPRIM
| ID: wpr-812385
ABSTRACT
Nine new ent-kaurane diterpenoids, named scopariusols L-T (1-9), were isolated from the aerial parts of Isodon scoparius. Their structures were characterized mainly by analyzing the NMR and HR-ESI-MS data, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 1 was active against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC value of 0.6 μmol·L.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Tests de criblage d'agents antitumoraux
/
Médicaments issus de plantes chinoises
/
Structure moléculaire
/
Chimie
/
Lipopolysaccharides
/
Cristallographie aux rayons X
/
Cellules HL-60
/
Résonance magnétique nucléaire biomoléculaire
/
Isodon
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Chinese Journal of Natural Medicines (English Ed.)
Année:
2018
Type:
Article
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