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Immunomodulatory activity of macromolecular polysaccharide isolated from Grifola frondosa / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.) ; (6): 906-914, 2015.
Article Dans Anglais | WPRIM | ID: wpr-812465
ABSTRACT
The present study was designed to evaluate the immune-modulating effects of the polysaccharide from Grifola frondosa (GFP) by using mouse peritoneal macrophage and cytoxan (CTX) induced immunosuppression models. Our results from the phagocytotic and mononuclear phagocytic system function assays showed that GFP-A (one component from GFP) stimulated the phagocytosis of the phagocytes. The splenocyte proliferation assay showed that GFP-A acted the effect combing ConA or LPS in splenocyte proliferation. The results showed that GFP-A increased indices of thymus and spleen, the levels of LDH and ACP in the spleen, the mRNA levels of IL-1β, IL-2, IL-6 and IFN-γ in splenocyte. And GFP-A also significantly increased the expression of CD4(+) and CD8(+) splenic T lymphocytes, which were suppressed by the CTX in peripheral blood. In conclusion, our results indicate that the GFP-A is involved in immunomodulatory effects leading to its modulatory effects on immunosuppression.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pharmacologie / Polyosides / Extraits de plantes / Lymphocytes T / Cellules cultivées / Chimie / Interleukine-6 / Grifola / Allergie et immunologie / Interleukine-1 bêta Type d'étude: Étude pronostique Limites du sujet: Animaux langue: Anglais Texte intégral: Chinese Journal of Natural Medicines (English Ed.) Année: 2015 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pharmacologie / Polyosides / Extraits de plantes / Lymphocytes T / Cellules cultivées / Chimie / Interleukine-6 / Grifola / Allergie et immunologie / Interleukine-1 bêta Type d'étude: Étude pronostique Limites du sujet: Animaux langue: Anglais Texte intégral: Chinese Journal of Natural Medicines (English Ed.) Année: 2015 Type: Article