Your browser doesn't support javascript.
loading
Anti-neuro-inflammatory effects of Nardostachys chinensis in lipopolysaccharide-and lipoteichoic acid-stimulated microglial cells / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.) ; (6): 343-353, 2016.
Article Dans Anglais | WPRIM | ID: wpr-812605
ABSTRACT
Excessive microglial cell activation is related to the progression of chronic neuro-inflammatory disorders. Heme oxygenase-1 (HO-1) expression mediated by the NFE2-related factor (Nrf-2) pathway is a key regulator of neuro-inflammation. Nardostachys chinensis is used as an anti-malarial, anti-nociceptive, and neurotrophic treatment in traditional Asian medicines. In the present study, we examined the effects of an ethyl acetate extract of N. chinensis (EN) on the anti-neuro-inflammatory effects mediated by HO-1 up-regulation in Salmonella lipopolysaccharide (LPS)- or Staphylococcus aureus lipoteichoic acid (LTA)-stimulated BV2 microglial cells. Our results indicated that EN suppressed pro-inflammatory cytokine production and induced HO-1 transcription and translation through Nrf-2/antioxidant response element (ARE) signaling. EN markedly inhibited LPS- and LTA-induced activation of nuclear factor-kappa B (NF-κB) as well as phosphorylation of mitogen-activated protein kinases (MAPKs) and signal transducer and activator of transcription (STAT). Furthermore, EN protected hippocampal HT22 cells from indirect neuronal toxicity mediated by LPS- and LTA-treated microglial cells. These results suggested that EN impairs LPS- and LTA-induced neuro-inflammatory responses in microglial cells and confers protection against indirect neuronal damage to HT22 cells. In conclusion, our findings indicate that EN could be used as a natural anti-neuro-inflammatory and neuroprotective agent.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pharmacologie / Acides teichoïques / Extraits de plantes / Lignée cellulaire / Chimie / Lipopolysaccharides / Facteur de transcription NF-kappa B / Microglie / Neuroprotecteurs / Mitogen-Activated Protein Kinases Limites du sujet: Humains langue: Anglais Texte intégral: Chinese Journal of Natural Medicines (English Ed.) Année: 2016 Type: Article

Documents relatifs à ce sujet

MEDLINE

...
LILACS

LIS

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pharmacologie / Acides teichoïques / Extraits de plantes / Lignée cellulaire / Chimie / Lipopolysaccharides / Facteur de transcription NF-kappa B / Microglie / Neuroprotecteurs / Mitogen-Activated Protein Kinases Limites du sujet: Humains langue: Anglais Texte intégral: Chinese Journal of Natural Medicines (English Ed.) Année: 2016 Type: Article