Total synthesis of neokotalanol, a potent α-glucosidase inhibitor isolated from Salacia reticulata / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 676-683, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-812642
ABSTRACT
Neokotalanol, a potent α-glucosidase inhibitor isolated from Salacia reticulata, was synthesized through a key coupling reaction between a perbenzylated thiosugar and an appropriately protected perseitol triflate derived from D-mannose. This key step was found to be quite temperature dependent, and a simultaneous cyclization of the triflate leading to a characteristic 2,4,7-trioxabicyclo[4.2.1]nonane system was detected.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Extraits de plantes
/
Chimie
/
Antienzymes
/
Salacia
/
Inhibiteurs des glycoside hydrolases
langue:
Anglais
Texte intégral:
Chinese Journal of Natural Medicines (English Ed.)
Année:
2013
Type:
Article
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