Isolation of cytotoxic compounds from the seeds of Crataegus pinnatifida / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 411-414, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-812660
ABSTRACT
AIM@#To study the chemical constituents and bioactivity of the seeds of Crataegus pinnatifida.@*METHODS@#The chemical constituents were isolated and purified by macroporous adsorptive resin D101, silica gel, and ODS column chromatography, and preparative HPLC. Their structures were elucidated on the basis of spectroscopic methods. In addition, the cytotoxic activities of compounds 1-4 were investigated on OPM2 and RPMI-8226 cells.@*RESULTS@#Four compounds were obtained and their structures were identified as (7S, 8S)-4-[2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-1-(hydroxymethyl)ethoxy]-3, 5-dimethoxybenzaldehyde (1), (+)-balanophonin (2), erythro-guaiacylglycerol-β-coniferyl aldehyde ether (3), buddlenol A (4).@*CONCLUSION@#Compound 1 is a novel norlignan, while compounds 1-4 exhibited marginal inhibition on the proliferation of OPM2 and RPMI-8226 cells.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Graines
/
Extraits de plantes
/
Structure moléculaire
/
Lignée cellulaire
/
Chimie
/
Crataegus
/
Prolifération cellulaire
/
Toxicité
/
Protéines de tissu nerveux
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Chinese Journal of Natural Medicines (English Ed.)
Année:
2013
Type:
Article
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