Ameliorating effect of new constituents from the hooks of Uncaria rhynchophylla on scopolamine-induced memory impairment / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 391-395, 2013.
Article
Dans En
| WPRIM
| ID: wpr-812664
Responsable en Bibliothèque :
WPRO
ABSTRACT
AIM@#To study the chemical constituents and their anti-amnesic effect from the hooks of Uncaria rhynchophylla.@*METHODS@#The isolation of compounds was performed by chromatographic techniques and their structures were identified on the basis of spectral analysis. Their ameliorating effects on scopolamine-induced memory impairment in vivo using a Morris water-maze task and passive avoidance task system were evaluated.@*RESULTS@#Activity-guided fractionation of the total extracts resulted in the isolation of four constituents, trans-anethole (1), p-anisaldehyde (2), estragole (3), and 3-oxo-olean-12-en-28-oic acid (4), which were found for the first time from this plant.@*CONCLUSION@#Compound 1 exhibited a better memory enhancing effect than tacrine, a positive agent, at the same dose in the passive avoidance test and a similar property in the water-maze test, and its action may be mediated, in part, by the acetylcholine enhancing cholinergic nervous system.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Scopolamine
/
Extraits de plantes
/
Structure moléculaire
/
Chimie
/
Rat Sprague-Dawley
/
Uncaria
/
Traitement médicamenteux
/
Mémoire
/
Troubles de la mémoire
Limites du sujet:
Animals
/
Humans
/
Male
langue:
En
Texte intégral:
Chinese Journal of Natural Medicines (English Ed.)
Année:
2013
Type:
Article