Single nucleotide polymorphism of the TP53 gene is not correlated with male infertility / 中华男科学杂志
National Journal of Andrology
;
(12): 142-146, 2017.
Article
Dans Chinois
| WPRIM
| ID: wpr-812796
ABSTRACT
Objective@#To investigate the correlation of the single nucleotide polymorphism (SNP) rs1042522 of the tumor protein p53 (TP53) gene with the risk of male infertility.@*METHODS@#This casecontrol study included 380 male patients with idiopathic infertility and 398 normal fertile men as controls from the Nanjing area. We genotyped the SNP rs1042522 of the TP53 gene by Sequence Mass Array and analyzed the correlation of the SNP with male infertility using the logistic regression model.@*RESULTS@#Compared with the normal controls, the patients with idiopathic infertility showed significantly decreased sperm concentration ([77.34±49.24] vs [13.13±24.96] ×106/ml), percentage of progressively motile sperm ([42.55±9.57] vs [10.38±5.57]%), serum testosterone level ([14.07±5.36] vs [11.89±4.50] nmol/L), and folliclestimulating hormone level ([16.80±18.20] vs [4.55±7.17] U/L) (P < 0.05) but no statistically significant differences in other parameters. No correlation was observed between the SNP frequencies and male infertility and similar results were found in the subgroups of the cases.@*CONCLUSIONS@#SNP rs1042522 of the TP53 gene is not significantly correlated with the risk of male infertility.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Numération des spermatozoïdes
/
Mobilité des spermatozoïdes
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Testostérone
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Sang
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Études cas-témoins
/
Modèles logistiques
/
Gènes p53
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Prédisposition génétique à une maladie
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Polymorphisme de nucléotide simple
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Hormone folliculostimulante
Type d'étude:
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Humains
/
Mâle
langue:
Chinois
Texte intégral:
National Journal of Andrology
Année:
2017
Type:
Article
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