Nucleotide polymorphism rs4880 of the SOD2 gene and the risk of male infertility / 中华男科学杂志
National Journal of Andrology
;
(12): 137-141, 2017.
Article
Dans Chinois
| WPRIM
| ID: wpr-812797
ABSTRACT
Objective@#To investigate the correlation of the single nucleotide polymorphism (SNP) rs4880 of the superoxide dismutase 2 (SOD2) gene with the risk of male infertility.@*METHODS@#This casecontrol study included 519 male patients with idiopathic infertility (aged 19-40 [28.93±4.93] years) in the case group and 338 fertile men (aged 19-40 [28.40±4.25] years) in the control group. We collected the clinical data, genotyped the SNP rs4880 of the SOD2 gene by Sequenom Mass Array, and analyzed the association of different genotypes with male infertility using the logistic regression model.@*RESULTS@#Statically significant differences were observed between the case and control groups in the level of folliclestimulating hormone (FSH) ([4.72±2.51] vs [15.65±17.24] U/L, P< 0.01), the percentage of progressively mobile sperm ([9.12±13.5] vs [41.95±9.03]%, P< 0.01), and sperm concentration ([12.95±24.38] vs [72.88±45.60] ×106/ml, P< 0.01), but not in other parameters. No correlation was found between male infertility and the heterozygous genotype TC (OR = 0.90, 95% CI 0.65-1.25, P = 0.516) or the homozygous genotype CC (OR=1.49, 95% CI 0.38-5.81, P = 0.566) as compared with the wild genotype TT, and similar results were obtained in the analysis of the subgroups.@*CONCLUSIONS@#The SNP rs4880 of the SOD2 gene was not correlated with male infertility, which, however, is to be supported by further studies with larger samples from more areas.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Mobilité des spermatozoïdes
/
Superoxide dismutase
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Sang
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Études cas-témoins
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Modèles logistiques
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Prédisposition génétique à une maladie
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Polymorphisme de nucléotide simple
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Hormone folliculostimulante
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Génétique
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Génotype
Type d'étude:
Etude d'étiologie
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Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Adulte
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
National Journal of Andrology
Année:
2017
Type:
Article
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