Sperm mitochondrial DNA and male infertility: An update / 中华男科学杂志
National Journal of Andrology
;
(12): 848-851, 2017.
Article
Dans Chinois
| WPRIM
| ID: wpr-812867
ABSTRACT
Sperm mitochondrial DNA (mtDNA) damage is closely related with male infertility. Lacking for the protection by histone and DNA-binding protein, sperm mtDNA is prone to the attack by reactive oxygen species (ROS) and, without an effective repair system of mtDNA, ROS-induced changes in mtDNA may damage the synthesis of mtDNA encoding proteins and affect the function of mitochondria, which may be an important genetic factor for male infertility. Related studies should focus on finding the causes of sperm mtDNA damage and its relationship with male infertility.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Spermatozoïdes
/
Altération de l'ADN
/
ADN mitochondrial
/
Espèces réactives de l'oxygène
/
Stress oxydatif
/
Génétique
/
Infertilité masculine
/
Mitochondries
Limites du sujet:
Humains
/
Mâle
langue:
Chinois
Texte intégral:
National Journal of Andrology
Année:
2017
Type:
Article
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