Research progress of copper transporter 1 in platinum-based chemotherapy / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1376-1379, 2018.
Article
Dans Chinois
| WPRIM
| ID: wpr-813123
ABSTRACT
Platinum drugs are widely used in the treatment of various solid tumors, but their resistance to platinum is the most significant obstacle to successful treatment. Copper transporter 1 (CTR1) is the specific transporter for copper, and it mainly locates at the plasma membrane and plays a role in pumping copper into the cell. CTR1 is also the major platinum influx transporter and plays a key role in platinum resistance. The expression, polymorphism, and degradation of CTR1 affect platinum resistance in tumors. Therefore, CTR1 may be a potential predictive biomarker of platinum resistance and a therapeutic target for overcoming platinum resistance.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Platine
/
Recherche
/
Cisplatine
/
Résistance aux médicaments antinéoplasiques
/
Cuivre
/
Transporteurs de cations
/
Utilisations thérapeutiques
/
Transporteur-1 du cuivre
/
Génétique
/
Métabolisme
langue:
Chinois
Texte intégral:
Journal of Central South University(Medical Sciences)
Année:
2018
Type:
Article
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