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NAPD regimen for patients with recurrent refractory diffuse large B-cell lymphoma / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences) ; (12): 754-759, 2018.
Article Dans Chinois | WPRIM | ID: wpr-813200
ABSTRACT
To investigate the clinical efficacy and toxicities for the NAPD regimen (vinorelbine, cytarabine, cisplatin, and dexamethasone) in the treatment of recurrent refractory diffuse large B-cell lymphoma.


Methods:

A total of 30 patients identified with recurrent refractory diffuse large B-cell lymphoma were enrolled in this retrospective study. The curative efficacy of NAPD regimen was evaluated after 2 consecutive cycles. The toxicities and adverse reaction were evaluated after 1 cycle. The objective response rate (ORR), overall survival (OS), progress free survival (PFS), and the rates of 1, 2, and 4-year OS and PFS were analyzed. The prognosis was evaluated with univariate analysis.


Results:

The ORR was 56.7% and clinical benefit rate (CBR) was 83.3% after 2 cycles. Five patients achieved complete remission, 12 achieved partial remission, and 8 achieved stable disease. The median OS was 22 (1.5-140) months. The 1, 2, and 4-year OS rates were 59.1%, 48.2%, and 40.2%, respectively. The median PFS was 14 (1.5-140) months. The 1, 2 and 4-year PFS rates were 56.3%, 42.2%, and 31.7%, respectively. The main adverse reaction was myelosuppression. Three patients suffered from grade III-IV leukopenia and 1 thrombocytopenia. Grade I-II gastrointestinal toxicity was 20%. No heart, liver, and kidney damages at grade III-IV were observed.


Conclusion:

The NAPD regimen is effective and its toxicity is well tolerated for the treatment of recurrent refractory diffuse large B-cell lymphoma. It is a salvage chemotherapy regimen worth to be verified.
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Vinblastine / Dexaméthasone / Protocoles de polychimiothérapie antinéoplasique / Études rétrospectives / Mortalité / Lymphome B diffus à grandes cellules / Cisplatine / Résultat thérapeutique / Thérapie de rattrapage / Cytarabine Type d'étude: Étude observationnelle / Étude pronostique Limites du sujet: Humains langue: Chinois Texte intégral: Journal of Central South University(Medical Sciences) Année: 2018 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Vinblastine / Dexaméthasone / Protocoles de polychimiothérapie antinéoplasique / Études rétrospectives / Mortalité / Lymphome B diffus à grandes cellules / Cisplatine / Résultat thérapeutique / Thérapie de rattrapage / Cytarabine Type d'étude: Étude observationnelle / Étude pronostique Limites du sujet: Humains langue: Chinois Texte intégral: Journal of Central South University(Medical Sciences) Année: 2018 Type: Article