Variations of beta-cell early-phase insulin secretion in type 2 diabetic patients in different stages / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 232-235, 2006.
Article
de Zh
| WPRIM
| ID: wpr-813727
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE@#To explore the variations of early-phase insulin secretion in Type 2 diabetic patients in different stages.@*METHODS@#L-arginine stimulative test, fast blood glucose and body mass index (BMI) were evaluated in 40 nomal controls (NC) and 101 Type 2 diabetic patients. The diabetic patients were divided into three groups: newly diagnosed group (n = 35), effectively treated by sulfonylureas group (n = 32) , and secondary failure of sulfonylureas group (n = 34). The indexs of insulin resistance of homeostasis model assessment (HOMA-IR), beta-cell insulin secretion of homeostasis model assessment (HOMA-IS), and the acute insulin response (AIRARG) index were calculated. Some statistical comparisons were done among the 4 groups.@*RESULTS@#The indexs of HOMA-IR in each group of Type 2 diabetic patients were all higher than those in NC group (P < 0.01). The AIRARG indexs were obviously lower in Type 2 diabetic patients in different stages than those in NC group (P < 0.01), and the subsequence from the highest to the lowest among the groups of diabetic patients was: the newly diagnosed group, the effectively treated by sulfonylureas group, and the secondary failure of sulfonylureas group (P < 0.01). But there was no significant difference in indexs of HOMA-IS between the newly diagnosed group and the effectively treated by sulfonylureas group.@*CONCLUSION@#There is severe insulin resistance in Type 2 diabetic patients in each stage. The variations of early-phase insulin secretion manifest a vary procedure of obvious deterioration by degrees from the newly diagnosed group to the secondary failure of sulfonylureas group in Type 2 diabetic patients.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Sulfonylurées
/
Facteurs temps
/
Insulinorésistance
/
Utilisations thérapeutiques
/
Diabète de type 2
/
Traitement médicamenteux
/
Cellules à insuline
/
Sécrétion d'insuline
/
Insuline
/
Métabolisme
Type d'étude:
Prognostic_studies
Limites du sujet:
Adult
/
Female
/
Humans
/
Male
langue:
Zh
Texte intégral:
Journal of Central South University(Medical Sciences)
Année:
2006
Type:
Article