Clinical significance of the expression of the RCAS1 mRNA and protein in astrocytic tumors / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 836-839, 2007.
Article
Dans Zh
| WPRIM
| ID: wpr-813790
Responsable en Bibliothèque :
WPRO
ABSTRACT
OBJECTIVE@#To determine the mRNA and protein expressions of RCAS1 in human astrocytic tumors, and to explore the relation between their expression and the genesis and development of tumor.@*METHODS@#The RCAS1 mRNA expression in human astrocytic tumors was evaluated by RT-PCR, and the RCAS1 protein expression was studied by immunohistochemical staining.@*RESULTS@#The quantities of RCAS1 mRNA expression between diffusive astrocytoma(Grade II) and anaplastic astrocytoma(Grade III), anaplastic astrocytoma and glioblastoma(Grade IV) were significantly different(P<0.05), while the expression scores of RCAS1 protein were different only between the anaplastic astrocytoma and glioblastoma(P<0.01). RCAS1 protein expression was positively correlated with the tumor grade (r=0.573,P<0.001). The RCAS1 protein was not detected in normal brain tissues by immunohistochemical staining.@*CONCLUSION@#The RCAS1 expression is related to the histological grade of astrocytic tumor. In astrocytic tumors, the RCAS1 expression is regulated transcriptionally and posttranscriptionally.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Astrocytome
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Tumeurs du cerveau
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ARN messager
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Génétique
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Métabolisme
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Antigènes néoplasiques
Limites du sujet:
Adolescent
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Adult
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Aged
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Child
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Child, preschool
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Journal of Central South University(Medical Sciences)
Année:
2007
Type:
Article