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Azoospermia factor microdeletion on Y chromosome in patients with idiopathic azoospermia or severe oligozoospermia / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences) ; (12): 241-245, 2007.
Article Dans Chinois | WPRIM | ID: wpr-813900
ABSTRACT
OBJECTIVE@#To investigate the correlation between male infertility and Y chromosome microdeletions of azoospermia factor (AZF) regions, and to establish a reliable genetic diagnosis in idiopathic infertile male patients with azoospermia or severe oligozoospermia.@*METHODS@#Multiplex PCR amplification of 6 sequence-tagged sites in AZF regions of the Y chromosome was examined among 100 normal karyotype male patients with azoospermia or oligozoospermia.@*RESULTS@#Four patients (4%) had Y chromosome microdeletions, the microdeletions of 3 patients were idiopathic azoospermic and those of the other 1 patient were secretory azoospermia.@*CONCLUSION@#The PCR-based Y chromosome microdeletion screening is simple and effective in the diagnosis of patients with severe male infertility. Microdeletion of Y chromosome is one of the major causes of severe dyszooospermia.
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Oligospermie / Délétion de segment de chromosome / Protéines du plasma séminal / Chromosomes Y humains / Diagnostic / Azoospermie / Locus génétiques / Génétique / Infertilité masculine / Caryotypage Type d'étude: Etude diagnostique Limites du sujet: Adulte / Humains / Mâle langue: Chinois Texte intégral: Journal of Central South University(Medical Sciences) Année: 2007 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Oligospermie / Délétion de segment de chromosome / Protéines du plasma séminal / Chromosomes Y humains / Diagnostic / Azoospermie / Locus génétiques / Génétique / Infertilité masculine / Caryotypage Type d'étude: Etude diagnostique Limites du sujet: Adulte / Humains / Mâle langue: Chinois Texte intégral: Journal of Central South University(Medical Sciences) Année: 2007 Type: Article