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Association of HTR2C-759C/T and -697G/C polymorphisms with antipsychotic agent-induced weight gain / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences) ; (12): 312-315, 2008.
Article Dans Chinois | WPRIM | ID: wpr-814078
ABSTRACT
OBJECTIVE@#To determine whether antipsychotic agent-induced weight gain was associated with 5-hydroxytryptamine 2C receptor (HTR2C) gene-759C/T and -697G/C polymorphisms.@*METHODS@#A case-matching controlled study was done. Eighty-five patients who had gained more than 7% of their pre-drug body weight served as a study group, and 85 patients who had gained less than 7% of their pre-drug body weight served as a control group. The control group were matched with the study group in the kinds of antipsychotic agents and the course of antipsychotic treatment. The ligation diction reaction technique was used to analyse the frequencies of HTR2C gene-759C/T and -697G/C polymorphisms.@*RESULTS@#The study group were more likely to be hemizygous for the -759C (for male) and the -759CC genotype (for female) than the control group. The study group were more likely to be hemizygous for the -697G (for male) and the -697CG/GG genotype (for female) (all P<0.05) than the control group.@*CONCLUSION@#The -759C/T and -697G/C polymorphisms of the promoter region of HTR2C gene may be associated with antipsychotic agent-induced weight gain.
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Polymorphisme génétique / Schizophrénie / Neuroleptiques / Prise de poids / Études cas-témoins / Régions promotrices (génétique) / Récepteur de la sérotonine de type 5-HT2C / Utilisations thérapeutiques / Traitement médicamenteux / Génétique Type d'étude: Étude observationnelle / Facteurs de risque Limites du sujet: Adolescent / Adulte / Femelle / Humains / Mâle langue: Chinois Texte intégral: Journal of Central South University(Medical Sciences) Année: 2008 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Polymorphisme génétique / Schizophrénie / Neuroleptiques / Prise de poids / Études cas-témoins / Régions promotrices (génétique) / Récepteur de la sérotonine de type 5-HT2C / Utilisations thérapeutiques / Traitement médicamenteux / Génétique Type d'étude: Étude observationnelle / Facteurs de risque Limites du sujet: Adolescent / Adulte / Femelle / Humains / Mâle langue: Chinois Texte intégral: Journal of Central South University(Medical Sciences) Année: 2008 Type: Article