Expression and significance of human beta-defensin in recurrent nasal polyps / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1119-1122, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-814141
ABSTRACT
OBJECTIVE@#To observe the expression of human beta-defensin-1 (hBD-1) and human beta-defensin-2 (hBD-2) in recurrent nasal polyps, and to investigate the role of beta-defensin in the recurrent nasal polyps.@*METHODS@#Tissues of nasal polyps was obtained from 10 patients with nasal polyps undergoing endoscopic sinus surgery, recurrent nasal polyps from 10 patients 6 months after surgery, nasal mucosa from 10 recovered patients with nasal polyps postoperatively and,10 control subjects. hBD-1 mRNA and hBD-2 mRNA levels of tissue specimens in all groups were detected by reverse transcriptase-polymerase chain reaction (RT-PCR).@*RESULTS@#There was no significant difference in hBD-1 mRNA level between the 4 groups (P>0.05). Expression of hBD-2 mRNA was detected in patients with nasal polyps and recurrent nasal polyps, but rare in the recovered patients and the control subjects.@*CONCLUSION@#hBD-1 is a constitutive expression and hBD-2 is an induced expression. beta-Defensin may play an important role in forming the nasal polyps.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Récidive
/
ARN messager
/
Études cas-témoins
/
Polypes du nez
/
RT-PCR
/
Bêta-Défensines
/
Génétique
/
Métabolisme
/
Muqueuse nasale
Type d'étude:
Étude observationnelle
Limites du sujet:
Adolescent
/
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Central South University(Medical Sciences)
Année:
2008
Type:
Article
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