Association of genetic polymorphism in phenylethanolamine-N-methyl transferase with essential hypertension in Changsha Han people / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1120-1125, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-814185
ABSTRACT
OBJECTIVE@#To investigate the association of phenylethanolamine-N-methyl transferase (PNMT) G-390A genetic polymorphism with risk of essential hypertension (EH) in Changsha Han people.@*METHODS@#A case-control association study was performed in 400 patients with essential hypertension (EH) and 388 normotensive subjects. PNMT G-390A was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-FRLP).@*RESULTS@#The genotype frequencies for the -390 GG, GA, and AA were 39.3%,50.0%, and 10.8%, respectively in EH patients, and were 43.6%,45.6%, and 10.8%, in normal subjects. No significant difference in either genotypic frequency (P=0.433) or allele frequency (P=0.378) of PNMT G-390A between EH patients and normals was observed. When by gender, there was significant difference in genotypic frequency (P0.05).@*CONCLUSION@#PNMT G-390A polymorphism is possibly associated with EH risk in male Chinese Han population in Changsha.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Phenylethanolamine n-methyltransferase
/
Polymorphisme génétique
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Données de séquences moléculaires
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Séquence nucléotidique
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Études cas-témoins
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Chine
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Facteurs sexuels
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Prédisposition génétique à une maladie
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Génétique
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Hypertension artérielle
Type d'étude:
Étude observationnelle
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Facteurs de risque
Limites du sujet:
Adulte
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Adulte très âgé
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Femelle
/
Humains
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Mâle
Pays comme sujet:
Asie
langue:
Chinois
Texte intégral:
Journal of Central South University(Medical Sciences)
Année:
2009
Type:
Article
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