Mutation analysis of neural cell adhesion molecules in human astrocytoma / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 510-514, 2009.
Article
Dans Zh
| WPRIM
| ID: wpr-814295
Responsable en Bibliothèque :
WPRO
ABSTRACT
OBJECTIVE@#To identify the function of neural cell adhesion molecule (NCAM) mutation in the genesis of human glioma.@*METHODS@#Mutations were found through polymerase chain reaction-single strand conformation polymorphism, and then the changed DNA fragments were purified and multiplied and sent to Shanghai for sequencing. Blast and ORF finder were used to find out the amino changes in NCAM.@*RESULTS@#An A-C transversion was found at position 1 126 in NCAM's 7 exon in a patient with glioblastoma from 43 astrocytoma.@*CONCLUSION@#Structural change in the protein caused by point mutation may be the reason for tumorigenesis of astrocytoma.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Astrocytome
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Tumeurs du cerveau
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Analyse de mutations d'ADN
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Données de séquences moléculaires
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Séquence nucléotidique
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Mutation ponctuelle
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Antigènes CD56
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Génétique
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Métabolisme
Limites du sujet:
Adult
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Journal of Central South University(Medical Sciences)
Année:
2009
Type:
Article