High fat diet induces obesity and alters the expression of MCHR1 and OB-Rb in the adipose tissue / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 823-829, 2011.
Article
Dans Chinois
| WPRIM
| ID: wpr-814500
ABSTRACT
OBJECTIVE@#To investigate the effect of high-fat (HF) diet on the body weight and the mRNA expression of melanin concentrating hormone receptor 1 (MCHR1) and leptin receptor (OB-Rb) in the adipose tissue in rats, the two important and opposite factors in regulating the body weight.@*METHODS@#Post-weaning rats were divided into 3 groups the NC group were fed a normal-chow diet (NC) (13% calories from fat), the HF group with a HF-diet (47% calories from fat) and the PHF group pair-fed a HF-diet (47% calories from fat). At the end of 8th week, the gained bodyweight, the plasma melanin concentrating hormone (MCH) and leptin, and the expression levels of MCHR1 and OB-Rb in the adipose tissue were measured.@*RESULTS@#Both the HF-diet and pair-fed HF-diet enhanced the body weight (P0.05).@*CONCLUSION@#Chronic intake of iso-caloric HF-diet and ad libitum HF-diet obviously results in increase in the body weight, serum leptin, and MCH concentration. Diet-induced obesity and related metabolic disorders are possibly correlated with up-regulated expression of MCHR1 and down-regulated expression of OB-Rb in the adipose tissue.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Hormones hypophysaires
/
Sang
/
ARN messager
/
Matières grasses alimentaires
/
Tissu adipeux
/
Récepteur somatostatine
/
Rat Sprague-Dawley
/
Leptine
/
Récepteurs à la leptine
/
Alimentation riche en graisse
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Journal of Central South University(Medical Sciences)
Année:
2011
Type:
Article
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