Influence of age on sedation for colonoscopy in adults / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To investigate the efficacy and risk of midazolam and propofol for sedation during colonoscopy procedures in adults of different age groups.@*METHODS@#A total of 180 patients undergoing colonoscopy were allocated to 3 groups a young adult group (n=45, 18-44 years), a mid-aged group (n=78,45-64 years) and an elderly group (n=57, 65-80 years). All patients were premedicated with midazolam 0.02-0.03 mg/kg and propofol 0.5-2.5 mg/kg. The pulse rate, arterial pressure, and oxygen saturation for each patient were monitored continuously before, during and after the procedure.@*RESULTS@#The doses of midazolam and propofol for the young adults were significantly higher than that for the mid-aged and the elderly (P0.05).@*CONCLUSION@#Higher dose of midazolam and propofol is needed to obtain the sedation quality in young adults. Whereas for the elderly, properly reducing the dose of midazolam and propofol may still keep the sedation quality during colonoscopy procedures.