Effect of extracts from Radix Trichosanthis on the expression of HBsAg and HBeAg in HepG2.2.15 cells / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 38-41, 2012.
Article
Dans Chinois
| WPRIM
| ID: wpr-814604
ABSTRACT
OBJECTIVE@#To investigate the effect of extracts with water and alcohol from Radix Trichosanthis on the cell survival and the expression of hepatitis B surface antigen (HBsAg) and hepatitis B e-antigen (HBeAg) in HepG2.2.15 cell supernatant.@*METHODS@#The cell survival rate of HepG2.2.15 cells was detected by MTT assay. The HBsAg and HBeAg in HepG 2.2.15 cell supernatant were evaluated by enzyme linked immunosorbent assay.@*RESULTS@#The water and alcohol soluble extracts from Radix Trichosanthis significantly inhibited the levels of HBsAg and HBeAg in HepG2.2.15 cells in a time-and-concentration-dependent manner. However, the therapeutic index of extracts with water from Radix Trichosanthis was better than that in the alcohol group.@*CONCLUSION@#The activity of water-soluble extract from Radix Trichosanthis is stronger on anti-hepatitis B virus than that of the alcohol-soluble extract.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Antiviraux
/
Pharmacologie
/
Médicaments issus de plantes chinoises
/
Virus de l'hépatite B
/
Classification
/
Cellules HepG2
/
Antigènes e du virus de l'hépatite virale B
/
Antigènes de surface du virus de l'hépatite B
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Central South University(Medical Sciences)
Année:
2012
Type:
Article
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