Differential expression of DJ-1 and HSP27 in invasive and non-invasive pituitary adenomas / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 481-484, 2012.
Article
Dans Chinois
| WPRIM
| ID: wpr-814647
ABSTRACT
OBJECTIVE@#To explore whether oncogenes DJ-1 and HSP27 are associated with invasiveness of human pituitary adenoma.@*METHODS@#Total proteins were extracted from samples of 20 invasive and 20 non-invasive pituitary adenomas and the expression of DJ-1 and HSP27 was analyzed by Western blot. The correlation of DJ-1and HSP27 with the invasiveness of pituitary adenoma was analyzed.@*RESULTS@#The strong positive rates of DJ-1 and HSP27 in the 20 invasive pituitary adenoma were 70% (14/20) and 80% (16/20), respectively. The invasive group had significantly higher expression of DJ-1 and HSP27 proteins than the noninvasive group [10% (2/20), 10% (2/20), respectively]. There was a positive correlation between the expression of DJ-1, HSP27 proteins and the invasiveness of pituitary adenoma as judged by the Spearman rank correlation test (P<0.05).@*CONCLUSION@#The proliferative activity and abnormal expression of oncogenes DJ-1 and HSP27 may play a significant role in tumorigenesis and progression of pituitary adenoma. There was a significant correlation between the expression of DJ-1 and HSP27 and the invasiveness of pituitary adenoma.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Tumeurs de l'hypophyse
/
Transduction du signal
/
Marqueurs biologiques tumoraux
/
Adénomes
/
Régulation de l'expression des gènes tumoraux
/
Protéines oncogènes
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Protéines et peptides de signalisation intracellulaire
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Protéines du choc thermique HSP27
/
Protein deglycase DJ-1
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Central South University(Medical Sciences)
Année:
2012
Type:
Article
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