MiR-519 inhibits gastric cancer cell activity through regulation of HuR expression / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 19-23, 2016.
Article
Dans Chinois
| WPRIM
| ID: wpr-815080
ABSTRACT
OBJECTIVE@#To investigate the role of miR-519 in regulating the cell activity of gastric cancer.
@*METHODS@#The expression of miR-519 was measured by qPCR. The protein expression of HuR was detected by Western blot. MTT assay was used to detect the cell activity of gastric cancer cells.
@*RESULTS@#The protein level of HuR in the gastric cancer cells was higher than that in the control cells. Over-expression of HuR resulted in the increase in the cell activity of gastric cancer (P<0.001). Suppression of HuR decreased the cell activity of gastric cancer (P=0.001). The miR-519 level in the gastric cancer cells was lower than that in the control cells (P=0.001). Over-expression of miR-519 decreased the protein level of HuR and the activity of gastric cancer cells.
@*CONCLUSION@#MiR-may inhibit the gastric cancer cell activity through suppression of HuR expression.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Tumeurs de l'estomac
/
Régulation de l'expression des gènes tumoraux
/
MicroARN
/
Lignée cellulaire tumorale
/
Prolifération cellulaire
/
Protéine-1 similaire à ELAV
/
Génétique
/
Métabolisme
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Central South University(Medical Sciences)
Année:
2016
Type:
Article
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