Progress in study on the role of exosome-derived microRNA in diagnosis and treatment of diseases / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1270-1275, 2015.
Article
Dans Chinois
| WPRIM
| ID: wpr-815342
ABSTRACT
Exosome is a kind of biological membrane structure at nanometer level. It is secreted by various cells in the body and widely distributed in most body fluids, such as saliva, blood, and milk. Biological active substances, including mRNAs, microRNAs, cytokines, and transcription factor, have been identified in the exosomes. MiRNAs are short and non-coding RNAs that modulate gene expression at the posttranscriptional level. MiRNAs extensively involves in henogenesis, cell proliferation and apoptosis. With various biological functions, exosome-derived miRNAs can not only be served as biomarkers to diagnose tumor, neurological diseases and mental disorders, but also possess potential as therapeutic targets.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Thérapeutique
/
Marqueurs biologiques
/
Apoptose
/
MicroARN
/
Prolifération cellulaire
/
Diagnostic
/
Exosomes
/
Génétique
/
Troubles mentaux
/
Tumeurs
Type d'étude:
Etude diagnostique
/
Étude pronostique
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Central South University(Medical Sciences)
Année:
2015
Type:
Article
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