Measurement of Rho-kinase and CD4+CD25+ regulatory T cells in the peripheral blood in asthmatic patients / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 577-581, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-815543
ABSTRACT
OBJECTIVE@#To determine the levels of Rho-kinase and CD4+CD25+ regulatory T cells in patients with asthma, and the relationship between Rho-kinase and CD4+CD25+ regulatory T cells.@*METHODS@#We included 16 patients with moderate to severe asthma in the research group and 14 healthy people as the control group. The levels of Rho-kinase in the 2 groups were measured by ELISA. The level of CD4+CD25+ regulatory T cells in the 2 groups was measured by flow cytometry. The pulmonary function was measured by spirometer.@*RESULTS@#The level of Rho-kinase in the research group was higher than that in the healthy controls (P0.05). The level of CD4+CD25+ regulatory T cells in the peripheral blood of the 2 groups showed a positive correlation with FEV1% (r=0.380, P=0.038). There was no correlation between the level of Rho-kinase and the level of CD4+CD25+ regulatory T cells in the peripheral blood of the 2 groups (r=-0.438, P>0.05).@*CONCLUSION@#Rho-kinase and CD4+CD25+ regulatory T cells may play a key role in the pathogenesis of asthma.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Asthme
/
Sang
/
Test ELISA
/
Études cas-témoins
/
Capacité vitale
/
Volume expiratoire maximal par seconde
/
Lymphocytes T régulateurs
/
Biologie cellulaire
/
Rho-Associated Kinases
/
Cytométrie en flux
Type d'étude:
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Central South University(Medical Sciences)
Année:
2014
Type:
Article
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