The role of mitochondrial membrane permeability transition pore in apoptosis / 医学研究生学报

ABSTRACT

Mitochondria play a central role in various apoptotic pathways within cells, changes of mitochondrial permeability transition(MPT) is the key point, which is mainly regulated by mitochondrial permeability transition pore(mPTP). So far, the structural model of mPTP, the way of mPTP participating in apoptosis and the regulatory nodes are still unclear. Our aim is to summarize mechanism of mitochondria mediate apoptosis, currently recognized structural model of mPTP, the pathological changes of all components of mPTP during apoptosis and the possible damage mechanisms underneath. mPTP is closely related to apoptosis, inhibit the opening of mPTP will reduce apoptosis. Therefore, interventions acting on inhibitomg mPTP opening can be helpful to prevent and treat diseases.