Advances in the role of neutrophil-derived reactive oxygen species in tumor / 医学研究生学报

ABSTRACT

Neutrophil is an important part of innate immune system, and plays a key role in resisting pathogen invasion and tumor immune surveillance. Meanwhile, neutrophil could produce reactive oxygen species , which are side products of cell metabolism. It is closely related to tumor development and progression. On the one hand, neutrophil could produce ROS to promote tumor growth and metastasis. On the other hand, it could also induce tumor cell death through different mechanisms. In this review, we summarize the roles of neutrophil- derived ROS in tumor development and discuss its prospects in cancer treatment.