The research advances of CAR-T cell therapy in solid tumor / 医学研究生学报

ABSTRACT

Chimeric antigen receptor T-cell immunotherapy (CAR-T) has gradually become a new therapeutic strategy for malignant tumor following more than 30 years of development. CAR-T therapy has achieved remarkable success in treating refractory hematological malignancies but less encouraging in solid tumors. There are many difficulties and challenges in the treatment of solid tumors such as low infiltration, immunosuppressive microenvironment, off-target effect. To overcome the limitation of CAR-T cells in the application of solid tumors, many new strategies were explored. Here, we will give a brief review on the recent progress about improvement approaches to improve the effectiveness of CAR-T cells in the treatment of solid tumors.