Research progress of exosome-derived microRNA in gastrointestinal tumors / 医学研究生学报

ABSTRACT

Exosome are nano-scale vesicles with a phospholipid bilayer membrane structure. They are widely distributed in body fluids such as serum, urine, and saliva, containing various biologically active substances such as RNA, DNA fragment and protein. Exosomes contain miRNAs called exosomal-derived miRNAs. Gastrointestinal tumors are one of the common malignant tumors. Effective screening and early diagnosis are clinical priorities and difficulties. Exosome-derived miRNAs in human circulation can be used as potential biomarkers for early diagnosis of digestive tract tumors. This article reviews the concepts and biological characteristics of exosomal-derived miRNAs, the detection of exosome-derived miRNAs and the relationship between exosome-derived miRNAs and digestive tract tumors.