Recent advances in tumor-associated neutrophils regulate the progression of gastric cancer / 医学研究生学报

ABSTRACT

Gastric cancer, which has very low 5-year survival rate, is a malignant tumor with high mortality around the world. In recent years, increasing attention has been paid to the effect of immunotherapy on cancer.Neutrophils in tumor immune microenvironment are associated with invasion, progression and prognosis of gastric cancer. Tumor-associated neutrophils can be classified into tumorsuppressor phenotype and tumorpromotion phenotype. Tumorsuppressor type can activate related cytokines to inhibit or kill tumor cells, while tumorpromotion type can secrete related chemical factors to promote the formation and progression of tumorand affect the prognosis of disease. This article reviews the mechanism of tumor-associated neutrophils in regulating the progression of gastric cancer.