Concurrent hepatitis D virus infection increases risk of hepatocellular carcinoma in patients with chronic hepatitis B / 临床肝胆病杂志

ABSTRACT

Concurrent hepatitis D virus (HDV) infection accelerates the progression of liver disease in patients with chronic hepatitis B and particularly increases the risk of hepatocellular carcinoma (HCC). Further studies are still needed to explore the carcinogenic mechanism of HDV, related treatment methods, and their clinical effects. This article reviews the new epidemiological characteristics of HDV-related HCC, the new understanding of the pathogenic mechanism of HDV, and the advances in diagnosis and treatment, which is of great significance to promote the development of accurate HDV detection methods and effective drugs and reduce HDV-related HCC.