Attenuation of oxidative stress and hepatic damage by some fermented tropical legume condiment diets in streptozotocin-induced diabetes in rats
Asian Pacific Journal of Tropical Medicine
;
(12): 692-697, 2012.
Article
Dans Anglais
| WPRIM
| ID: wpr-819624
ABSTRACT
OBJECTIVE@#To investigate the modulatory effect of fermented legume condiments diet on oxidative stress in streptozotocin (STZ) induced diabetic rats.@*METHODS@#Adult male Wistar rats were randomly divided into six groups with six animals in each group. Diabetes was induced by intraperitoneal injection of STZ (35 mg/kg b.w.). After being confirmed diabetic, the rats were fed with fermented Bambara groundnut, Locust bean and Soybean diets for 14 days. The plasma was obtained after 14-day treatment and analyzed for hepatic damage marker enzymes (AST, ALT and ALP) and in vivo antioxidant indices.@*RESULTS@#The diabetic untreated rats showed elevated (P<0.05) levels of AST, ALT, ALP and malondialdehyde with reduced activities of glutathione-S-transferase, catalase as well as plasma reduced glutathione, vitamin C and total protein content. However, treatment of diabetic rats with fermented legume condiments diets for 14 days significantly (P<0.05) reversed the above parameters towards normalcy, suggesting their modulation of oxidative stress, which may be due to their high phenolic content and antioxidant capacity.@*CONCLUSIONS@#The attenuation of oxidative stress and protection of hepatic tissue damage by the legume condiment diets in STZ induced diabetic rats compare favourably with that of metformin, a well known oral hypoglycemic drug.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Marqueurs biologiques
/
Répartition aléatoire
/
Rat Wistar
/
Stress oxydatif
/
Préparations à base de plantes
/
Diabète expérimental
/
Traitement médicamenteux
/
Enzymes
/
Fermentation
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Asian Pacific Journal of Tropical Medicine
Année:
2012
Type:
Article
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