Expression and significance of E-cadherin, N-cadherin, transforming growth factor-β1 and Twist in prostate cancer
Asian Pacific Journal of Tropical Medicine
; (12): 76-82, 2014.
Article
de En
| WPRIM
| ID: wpr-819726
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE@#To study the expression of E-cadherin, N-cadherin, TGF-β1 and Twist protein and investigate its significance in the occurrence and development of prostate cancer.@*METHODS@#The expression of E-cadherin, N-cadherin, TGF-β1 and Twist protein in 59 prostate cancer tissues and 21 adjacent tissues were detected by immunohistochemical SABC staining, and the correlation with clinicopathological features was analyzed.@*RESULTS@#Positive rates of E-cadherin, N-cadherin, TGF-β1 and Twist were 32.2%, 54.2%, 71.2% and 74.6%, respectively, in prostate cancer tissues and 85.7%, 9.52%, 19.0% and 9.52%, respectively, in cancer-adjacent tissues, with significant differences between the two groups (P20μg/L group, but the positive expression of Twist was not significant between groups. The expression of E-cadherin was highly negatively correlated with that of N-cadherin and also highly negatively correlated with that of Twist. The expression of TGF-β1 was correlated with those of E-cadherin, N-cadherin and Twist.@*CONCLUSIONS@#The reduced expression of E-cadherin, abnormal expression of N-cadherin, transformation form E-cadherin to N-cadherin and the increased expression of TGF-β1 and Twist play an important role in the occurrence and development of prostate cancer.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Tumeurs de la prostate
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Cadhérines
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Statistique non paramétrique
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Lignée cellulaire tumorale
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Protéine-1 apparentée à Twist
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Facteur de croissance transformant bêta-1
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Métabolisme
Limites du sujet:
Humans
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Male
langue:
En
Texte intégral:
Asian Pacific Journal of Tropical Medicine
Année:
2014
Type:
Article