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Relationship between expression of COX-2, TNF-α, IL-6 and autoimmune-type recurrent miscarriage
Asian Pacific Journal of Tropical Medicine ; (12): 990-994, 2013.
Article Dans Anglais | WPRIM | ID: wpr-819743
ABSTRACT
OBJECTIVE@#To investigate the roles of COX-2, TNF-α, IL-6 in the pathogenesis of autoimmune-type recurrent spontaneous abortion (RSA).@*METHODS@#RT-PCR was used to detect the mRNA of COX-2, TNF-α, IL-6 in the trophoblast cells of murine RSA and normal pregnant models. The COX-2, TNF-α, IL-6 protein expressions were determined by using immunohistochemisry staining method. The COX-2, TNF-α, IL-6 protein expressions were determined by ELISA.@*RESULTS@#The embryo loss rates in experiment group was significantly higher than that in normal pregnancy control group, the expression of COX-2, TNF-α, IL-6 in the trophoblast cells of murine RSA and normal pregnant models. The expression of COX-2 in autoimmune-type recurrent spontaneous abortion was significantly lesser than in normal pregnant models. The expression of TNF-α, IL-6 in autoimmune-type recurrent spontaneous abortion was significantly higher than in normal pregnant models. There was a positively correlation between TNF-α and IL-6. There was no relationship between COX-2, TNF-α and IL-6.@*CONCLUSIONS@#The abnormal expression of COX-2, TNF-α and IL-6 may result in RSA.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Trophoblastes / Sang / Auto-immunité / Chimie / Avortements à répétition / Interleukine-6 / Facteur de nécrose tumorale alpha / Statistique non paramétrique / Relations mère-foetus / Modèles animaux de maladie humaine Type d'étude: Étude pronostique Limites du sujet: Animaux langue: Anglais Texte intégral: Asian Pacific Journal of Tropical Medicine Année: 2013 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Trophoblastes / Sang / Auto-immunité / Chimie / Avortements à répétition / Interleukine-6 / Facteur de nécrose tumorale alpha / Statistique non paramétrique / Relations mère-foetus / Modèles animaux de maladie humaine Type d'étude: Étude pronostique Limites du sujet: Animaux langue: Anglais Texte intégral: Asian Pacific Journal of Tropical Medicine Année: 2013 Type: Article