Antimalarial potency of the leaf extract of Aspilia africana (Pers.) C.D. Adams
Asian Pacific Journal of Tropical Medicine
;
(12): 126-129, 2012.
Article
Dans Anglais
| WPRIM
| ID: wpr-819813
ABSTRACT
OBJECTIVE@#To investigate the antimalarial activity of ethanol extract of Aspilia africana (A. africana) leaf.@*METHODS@#The ethanol extract of A. africana leaf (100-400 mg/kg) was screened for blood schizonticidal effect against chloroquine-sensitive Plasmodium berghei (P. berghei) in mice both in early and established models of antimalarial studies.@*RESULTS@#The leaf extract exhibited significant (P<0.05) antiplasmodial activity in 4-day early infection and in established infection tests with a considerable mean survival time comparable to that of standard drug, chloroquine (10 mg/kg).@*CONCLUSIONS@#The findings show that ethanol extract of A. africana leaf possesses potent antiplasmodial activity which justify the use in ethnomedicine and can be developed in malaria therapy.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Plasmodium berghei
/
Solvants
/
Extraits de plantes
/
Chimie
/
Analyse de variance
/
Feuilles de plante
/
Asteraceae
/
Éthanol
/
Traitement médicamenteux
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Asian Pacific Journal of Tropical Medicine
Année:
2012
Type:
Article
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