Bioinformatics analysis of breast cancer bone metastasis related gene-CXCR4
Asian Pacific Journal of Tropical Medicine
;
(12): 732-738, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-819975
ABSTRACT
OBJECTIVE@#To analyze breast cancer bone metastasis related gene-CXCR4.@*METHODS@#This research screened breast cancer bone metastasis related genes by high-flux gene chip.@*RESULTS@#It was found that the expressions of 396 genes were different including 165 up-regulations and 231 down-regulations. The expression of chemokine receptor CXCR4 was obviously up-regulated in the tissue with breast cancer bone metastasis. Compared with the tissue without bone metastasis, there was significant difference, which indicated that CXCR4 played a vital role in breast cancer bone metastasis.@*CONCLUSIONS@#The bioinformatics analysis of CXCR4 can provide a certain basis for the occurrence and diagnosis of breast cancer bone metastasis, target gene therapy and evaluation of prognosis.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Tumeurs osseuses
/
Tumeurs du sein
/
Données de séquences moléculaires
/
Régulation de l'expression des gènes tumoraux
/
Régulation positive
/
Chimie
/
Alignement de séquences
/
Séquence d'acides aminés
/
Biologie informatique
Limites du sujet:
Adulte
/
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Asian Pacific Journal of Tropical Medicine
Année:
2013
Type:
Article
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