-592 and -1082 interleukin-10 polymorphisms in pulmonary tuberculosis with type 2 diabetes
Asian Pacific Journal of Tropical Medicine
;
(12): 505-509, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-820010
ABSTRACT
OBJECTIVE@#To determine the polymorphisms of Interleukin-10 (IL-10) (-592, -1082) in pulmonary tuberculosis (PTB) with and without type 2 diabetes (T2D).@*METHODS@#We studied a Mexican mestizo population of 37 patients with TB in remission (TBr) and 40 with active pulmonary TB (PTB), 21 patients with TB + T2D, 47 blood donors accepted, and 13 healthy health-care workers with tuberculin skin test positive. Determination of IL-10 polymorphisms was performed by real-time Polymerase chain reaction.@*RESULTS@#IL-10-592C/A presented in a greater proportion in healthy individuals than in patients with type 2 diabetes and TB in a not quite significant statistically manner. IL-10-1082A/A presented more frequently in the group of patients with both diseases, not being statistically significant in comparison with the group of healthy subjects.@*CONCLUSIONS@#This study describes two important new findings. First, it reveals that the IL-10 (-592 A/A and -592 C/C) polymorphisms were found in a greater proportion in a group of patients with T2D and TB than in healthy subjects. Second, the study provides evidence that the (-1082 G/G) polymorphism presented with greater frequency in healthy individuals than in patients with both of these diseases.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Tuberculose pulmonaire
/
Américain origine mexicaine
/
Interleukine-10
/
Polymorphisme de nucléotide simple
/
Diabète de type 2
/
Réaction de polymérisation en chaine en temps réel
/
Fréquence d'allèle
/
Génétique
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Asian Pacific Journal of Tropical Medicine
Année:
2013
Type:
Article
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