Hepatoprotective and antioxidant properties of marine halophyte Luminetzera racemosa bark extract in CCL(4) induced hepatotoxicity
Asian Pacific Journal of Tropical Medicine
; (12): 462-465, 2011.
Article
de En
| WPRIM
| ID: wpr-820109
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE@#To identify the hepatoprotective and antioxidant activity of Luminetzera racemosa (L. racemosa) bark extract.@*METHODS@#Wistar albino rats were divided into 6 groups: Group 1 served as control; Group 2 served as hepatotoxin (CCL(4) treated) group; Group 3 served as positive control (Silymarin) treated groups; Group 4, 5 and 6 served as (100, 200 and 300 mg/kg bw p.o.) L. racemosa bark extract treated groups. Moreover, in vitro antioxidant indexes, including DPPH, hydroxyl radical scavenging activity (HRSA), NO, ferric reducing antioxidant power (FRAP), lipid hydroperoxide (LPO) and super oxide dismutase (SOD) were also analyzed in the bark extract.@*RESULTS@#The results suggested that, the level of serum glutamate oxyloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), alkaline phosphatise (ALP), bilurubin, cholesterol, sugar and lactate dehydrogenase (LDH) were significantly (P<0.05) increased in hepatotoxin treated rats when compared with the control group. But, the maximum reduction of SGOT [(225.36±13.65) IU/L], SGPT [(96.85±17.36) IU/L], ALP [(315.37±17.16) IU/L], bilirubin [(2.97±0.46) mg/dL], cholesterol [(163.73±17.54) mg/dL], sugar [(127.35±27.35) mg/dL] and LDH [(1 784.00±268.36) IU/L] were observed with 300 mg/kg bw of bark extract treated rats. Histopathological scores showed that, no visible changes were observed with high dose (300 mg/kg bw) of bark extract treated rats except mild fatty changes. The in vitro antioxidant assays showed that, the IC(50) values were observed as (44.17±6.87) μg/mL, (42.45±2.81)μg/mL, (62.37±3.98)μg/mL, (54.24±3.09)μg/mL, (87.25±5.90) μg/mL and (71.54±5.42)μg/mL for DPPH, HRSA, NO, FRAP, LPO and SOD radical scavenging activities, respectively.@*CONCLUSIONS@#The hepatoprotective and antioxidant activities of the bark extract might be to the presence of unique chemical classes such as flavonoids, alkaloids and polyphenols.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacologie
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Aspartate aminotransferases
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Sang
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Tétrachloro-méthane
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Extraits de plantes
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Rat Wistar
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Écorce
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Alanine transaminase
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Toxicité
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Plantes tolérantes au sel
Type d'étude:
Prognostic_studies
Limites du sujet:
Animals
langue:
En
Texte intégral:
Asian Pacific Journal of Tropical Medicine
Année:
2011
Type:
Article