Expression of NF-κB and osteopontin of synovial fluid of patients with knee osteoarthritis
Asian Pacific Journal of Tropical Medicine
;
(12): 379-382, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-820513
ABSTRACT
OBJECTIVE@#To explore the significance of osteopontin and nuclear factor κB (NF-κB) expression in patients with knee osteoarthritis.@*METHODS@#RT-PCR and enzyme-linked immunosorbent assay were used to measure the Osteopontin (OPN) and NF-κB concentration of knee joint synovial fluid of patients with knee osteoarthritis and trauma fractures, and analyze the relationship between the expressiones of them.@*RESULTS@#OPN and NF-κB expression at the mRNA and protein levels of patients with knee osteoarthritis were significantly higher than the control group. the result showed statistical significance (P<0.05). There was a positive correlation between the OPN levels in synovial fluid of patients with knee osteoarthritis and NF-κB expression levels (P<0.05).@*CONCLUSIONS@#The high expression of OPN and NF-κB are closely related to occurrence and development of knee osteoarthritis.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Synovie
/
ARN messager
/
Études cas-témoins
/
Technique de Western
/
Réaction de polymérisation en chaîne
/
Facteur de transcription NF-kappa B
/
Statistique non paramétrique
/
Gonarthrose
/
Ostéopontine
/
Génétique
Type d'étude:
Étude observationnelle
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Asian Pacific Journal of Tropical Medicine
Année:
2013
Type:
Article
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