Analysis of bacterial detection in children with acute lung injury (respiratory distress syndrome) / 公共卫生与预防医学

ABSTRACT

Objective To investigate the distribution of pathogenic bacteria and the results of drug sensitivity test in children with acute lung injury (respiratory distress syndrome), so as to guide rational clinical drug use. Methods A total of 254 cases of children diagnosed with acute lung injury (respiratory distress syndrome) in Wuhan Children's Hospital from May 2017 to May 2019 were retrospectively analyzed. Sputum samples were collected from all children for pathogenic microorganisms detection and drug sensitivity test. Results Of 127 strains of pathogenic bacteria were isolated from 254 children. Gram-negative bacilli were the main pathogenic bacteria, among which 38 strains of acinetobacter baumannii were infected, accounting for 29.92%, and 13 strains of pseudomonas aeruginosa were infected, accounting for 10.23%. There were 10 strains of stenotrophomonas maltophilia (7.87%) and 42 strains of fungal infection (33.07%). There were 26 cases of mixed infection, of which 16 cases were infected with acinetobacter baumannii and candida albicans, accounting for 61.54%. Acinetobacter baumannii was resistant to a variety of antibacterial drugs and had a sensitivity of >50% to imipenem. Conclusion Gram-negative bacilli were the main pathogenic bacteria in children with acute lung injury (respiratory distress syndrome). Given that acinetobacter baumannii with the highest infection rate is resistant to various drugs, it is necessary to dynamically detect the resistance of pathogenic bacteria and reasonably choose antimicrobial agents for treatment.