Drug resistance analysis of Myroides odoratimimus producing MUS-1 carbapenemase / 临床检验杂志

ABSTRACT

Objective@#To investigate the clinical and microbiological characteristics of Myroides odoratimimus producing MUS-1 carbapenemase. @*Methods@#A strain of gram-negative bacterium isolated from the urine sample of one patient hospitalized in the oncology department of Affiliated Hospital of Xuzhou Medical University was identified by the Vitek 2 automatic microbial analyzer and 16S RNA sequencing, and its bla MUS-1 gene was detected with PCR. The minimum inhibitory concentrations (MICs) of antimicrobial drugs were determined by the broth dilution method. @*Results@#One strain of MUS-1 carbapenemase producing Myroides odoratimimus was found. The drug susceptibility test showed that it was resistant to most of antibiotics conventionally used, but sensitive to minocycline and meropenem, the MIC of imipenem was 8 μg/mL, which was judged as intermediate. @*Conclusion@#The bla MUS-1 gene may be the cause leading Myroides odoratimimus to resistant carbapenems drugs.